Meet the WPP Team​

Meet the Research team

Our research team consists of health professionals and scientists from different disciplines and backgrounds, all working towards our common goal of precision prevention of women’s cancers.

We work in close collaboration with the Cancer Prevention Trials Unit and Barts Clinical Trials Unit.

Learn about the WPP Clinical team here!

Our team

The Queens Hotel was where the first public appeal was held in the charity's history - a special luncheon not unlike this one
Yorkshire Cancer Research marking 100 years, at a special event at the Queens Hotel – Picture date Wednesday 21 May, 2025 (Leeds, West Yorkshire)
Photo copyright, contact for licensing. For licensed images, credit should read: Jonathan Pow/jp@jonathanpow.com (REF: POW_250521_8256)

Ranjit Manchanda

Professor Ranjit Manchanda joined QMUL as Senior Lecturer in 2015. He was appointed as Professor of Gynaecological Oncology at Wolfson Institute of Population Health (WIPH), QMUL in Sep 2019, and co-leads the Screening, Prevention and Epidemiology Unit at the Centre for Cancer Screening, Prevention and Early Diagnosis at WIPH. He is a Consultant Gynaecological Oncologist at Barts Health NHS Trust and leads the Women’s Precision Prevention Service.

Prof Manchanda completed a NIHR Academic Clinical Lectureship at UCL and subspecialty training in Gynaecological Oncology at UCLH and Barts Health.

He is an Honorary Professor at the Department of Health Services Research, London School of Hygiene & Tropical Medicine. He is a Commissioner, Lancet Commission on Ovarian Cancer and Co-Leads the commission’s SPED Working group. He is a member of several advisory and oversight committees and was the Topic Advisor (Clinical Lead) for NICE Guideline [NG241]. He is an NHS Innovation Accelerator (NIA) Alumnus. 

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Michail Sideris

Michail is a Consultant Gynaecological Oncologist at the Royal London Hospital and an Honorary Senior Clinical Lecturer at Queen Mary University of London. He completed his academic subspecialty training at the Royal London Hospital. He completed his doctorate thesis in molecular biomarkers of early rectal cancer at King’s College London and has published over 90 peer reviewed articles. He has also completed an MSc in Cancer Genomics and Data Science in 2025.

Dr-Caitlin-Fierheller

Caitlin Fierheller

Caitlin joined the Women’s Precision Prevention team as Postdoctoral Research Associate in February 2023. She is currently working across clinical trials in the WPP team and is a co-investigator on the PROTECT-C and DETECT-2 studies.

She completed her PhD in Human Genetics at McGill University, Montreal, Canada in 2023. Her research focused on the molecular genetics of germline potentially pathogenic variants in DNA repair pathway genes in familial ovarian cancer. She obtained her BSc in 2016 in Genetics and Biochemistry from Western University, London, Canada.

Jacqueline 2

Jacqueline Sia

Jacqueline is an Academic Clinical Lecturer in Gynaecological Oncology. Her research is on evaluating strategies to improve surgical prevention outcomes of high grade serous ovarian cancer. This includes population-based genetic testing to improve genetic risk ascertainment, improving histopathological diagnosis and management of STIC, and exploring novel OC surgical prevention strategies.

Jacqueline studied Medicine at the University of Glasgow. She completed her PhD in prevention of ovarian cancer under the supervision of Prof Ranjit Manchanda.

Dr-Subhasheenee-Ganesan

Subhasheenee Ganesan

Subha is a Clinical Research Fellow and PhD student in Gynaecological Oncology. Her research is on the risk of serous endometrial cancer in BRCA carriers and the role of preventive hysterectomy, and the acceptability of risk-reducing hysterectomy and Mirena coil at their relevant cost-effective lifetime risk thresholds for women at increased risk of womb cancer.

Subha studied Medicine at Barts and The London School of Medicine and Dentistry and is a Specialty Trainee in Obstetrics and Gynaecology in the West Yorkshire Deanery.

Priyanka

Priyanka Deshmukh

Priyanka is a Clinical Research Fellow in Gynaecological Oncology and MRes Student at Queen Mary University of London. Her research focuses on hereditary endometrial cancers and Lynch Syndrome through the LEGACY Study, and on implementing precision prevention and genetic testing pathways across ovarian, endometrial, and colorectal cancers via the DETECT-2 trial. She completed her undergraduate and postgraduate medical training in Mumbai, India, before joining the specialty training programme in the East of England, UK.

Roisin

Roisin Mulholland

Roisin is a Clinical Research Fellow and MRes student in Gynaecological Oncology. Her research is on improving early detection of ovarian cancer through ovarian cancer symptoms and novel biomarkers. She is also working on the OVACATCH programme which aims to improve ovarian cancer screening in high risk women using multimarker models. Roisin studied Medicine at the University of Edinburgh and is a Specialty Trainee in Obstetrics and Gynaecology in the West of Scotland Deanery.  

Lili Ellison

Lili Ellison

Lili is a Clinical Research Fellow in Gynaecological Oncology. Lili studied Medicine at the University of Birmingham and is a Specialty Trainee in Obstetrics and Gynaecology in the South London deanery.  Her research is on the risk of serous endometrial cancer in BRCA carriers and the role of preventive hysterectomy, and other projects which cover risk ascertainment and risk-reducing strategies encompassing medical and surgical prevention for women’s cancers. She is also part of the central coordinating team of PROTECTOR.

Yuxiao

Yuxiao Sun

Yuxiao is a PhD student in health economics at the London School of Hygiene and Tropical Medicine, working closely with Queen Mary University of London. Her research focuses on model-based economic evaluation of genetic testing.

Yuxiao completed her MSc in Health Economics at the University of York. She has experience in conducting health economic evaluations as a research assistant and modeller at the University of Sheffield before joining WPP.

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Lucy Mitchinson

Lucy is a Postdoctoral Research Associate in Behavioural Science. She is a mixed-methods researcher with an interest in health systems and health inequality. Her work in recent years has focused on understanding the barriers to cancer diagnosis and treatment.

Her previous work explored; GP cancer referrals, rapid research into care delivery during health emergencies, and in-depth interviews with hospice staff and patients. She completed her PhD in the Marie Curie Palliative Care Research Department of University College London.

Jingsong

Jingsong Zhao

Jingsong is a Postdoctoral Research Associate in Behavioural Science. She is academically trained as a behavioral scientist and her research focuses on family-wide risk communication in the context of hereditary cancers. 

Jingsong holds a Master of Public Health from Washington University in St. Louis and a PhD in Behavioral, Social, and Health Education Sciences from Emory University.

Hamda-Mohamed

Hamda Mohamed

Hamda is a Clinical Nurse Specialist. Her work will be focused primarily on providing virtual counselling and genetic testing support for cancer patients and/or unaffected individuals who are considering or undergoing genetic testing within research studies being undertaken in the Women’s Precision Prevention team in the Cancer Prevention Unit.

She completed her BSc in Adult Nursing in 2020 at King’s College London. She has nursing experience in haematology oncology, dermatology and rare diseases.

Grace Norman

Grace Norman

Grace is a Clinical Genetic Counsellor (GC). Her work will be focused primarily on providing counselling and support to patients who are undergoing genetic testing within research studies being undertaken in the Women’s Precision Prevention team in the Cancer Prevention Unit. Grace completed her BSc in Genetics at Stellenbosch University, South Africa. She then went on to complete her masters in Genetic and Genomic Counselling at Cardiff University. Grace has worked in a regional genetics service for the NHS in London before she joined the WPP team in February 2025. 

Dona

Dona Chakraborty

Dona is a Genetics Counsellor/Clinical Nurse Specialist. She has been in the field of cancer research for over 8 years on cancer biology, genetic counselling and nurse-led programmes. She has been working in various regional cancer institutes of India before joining the WPP team as genetic counsellor/clinical nurse specialist in the PROTECT-C and DETECT-2 studies.

Laura-White

Laura White

Laura is the Head of Clinical Trial Management of Barts Clinical Trials Unit. She has a BSc degree in Neuroscience at University of Leeds and a Post-Graduate Diploma in Public Health from London School of Hygiene and Tropical Medicine. She provides operational oversight for all clinical trial activities within the unit including trial management, data management and quality assurance.
Wythehi-Ambihapathy

Wythehi Ambihapathy

Wythehi joined the Barts CTU at QMUL as a Clinical Trial Manager in February 2023. She is working in Prof Manchanda’s Women’s Precision Prevention (WPP) team, and leads the project management of the DETECT-2 (Direct to patient testing at cancer diagnosis for precision prevention-2) study as well as supporting work on the wider trials portfolio. In this role she provides operational oversight/support for clinical trial activities, including trial management, data management and vendor management.
Bhagyashree-Ingle

Bhagyashree Ingle

Bhagyashree is a senior software engineer in Women’s Precision Prevention team. She has a Bachelor of Engineering degree in Computer Science. She has been working with QMUL for last 5 years and delivered several applications for research clinical trial studies independently. She is highly experienced in requirement gathering, analysis, design, development, support and maintenance of the clinical trials.

She has recently delivered DETECT-2(Direct to patient testing at cancer diagnosis for precision prevention-2) trial, providing support and maintenance for the same. She is currently working on PROTECT-C (Population Based Germline Testing for Early Detection and Prevention of Cancer) trial.

Victoria-White

Victoria White

Victoria is Executive Assistant to Prof Manchanda. She provides administrative support to the Women’s Precision Prevention Research Team.

Chiara

Chiara Caricato

Chiara is a Visiting Research Fellow from Italy (Rome, Gemelli University Hospital), where she contributes to precision prevention projects aimed at enhancing early risk detection, improving long-term outcomes, and promoting preventive surgery in women at increased risk. She is currently engaged in the PROTECTOR, DETECT-2, and PROTECT-C studies. Her research interests include patient-centered care, translational research, multidisciplinary collaboration, and innovation in cancer prevention.

Rosie Corbie

Rosie Corbie

Rosie is a Genetic Counsellor in the Women’s Precision Prevention team. She helps patients taking part in research studies by providing genetic counselling and support around genetic testing. Rosie completed her BSc in Biological Sciences at University College London and her MSc in Clinical Sciences (Genomic Counselling) at the University of Manchester, as part of the Scientist Training Programme. She undertook her clinical training at the North West Thames Regional Genetics Service, gaining broad experience across cancer, rare disease, and prenatal genetics.

Yasmin

Yasmin Sharif​

Yasmin completed her BSc in Nursing at the University of West London and has experience in haematology/oncology. She worked as a nurse at Barts Health for four years, specialising in chemotherapy administration and the care of patients pre- and post-stem cell transplant.

Sheetal

Sheetal Karavadra

Sheetal joined QMUL in September 2024 and started as a Trial Coordinator with Prof Manchanda’s Women’s Precision Prevention (WPP) team in January 2026. She holds a BSc in Human Biosciences and has worked in clinical trials since 2020. Her experience includes large-scale screening studies such as NHS-Galleri and the SUMMIT Study. In her current role, she primarily supports trial activities across the DETECT-2 and PROTECT-C studies.

Ling

Ling Shao

Ling joined the QMUL in April 2025 and started as a Trial Facilitator for PROTECTOR trial. She has worked in UK clinical trials since 2024. She supports the delivery of study and engagements with participating sites and stakeholders.

She holds BSc from University of Bristol and MSc from UCL in life sciences. 

Lotta Coenen

Lotta Coenen

Lotta is a General Practitioner (GP) in Brussels, Belgium and a PhD-student at the Vrije Universiteit Brussel. Her research is focused on the acceptability and feasibility of universal access to BRCA1/2-testing through the GP in Belgium. Within the WPP-team she is focusing on a cost-effective analysis of population BRCA1/2 testing.

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Amanda Dibden​

Amanda joined the WIPH in 2011 as a statistician, working on various projects to evaluate the effectiveness of breast cancer screening. After completion of her PhD in 2024, she joined the WPP team and provides statistical support for a variety of projects including the PRESCORES study.

Honorary team members

Xia-Wei

Xia Wei

Xia is an honorary postdoctoral research fellow in Health Economics. She has published cost-effective analyses which have informed the NICE guideline on familial ovarian cancer, and is currently working on identifying the cost-effective lifetime breast cancer risk threshold for risk-reducing mastectomy.

Dr Samuel Oxley

Samuel Oxley

Sam is a Subspecialty Trainee in Gynaecological Oncology at the Royal London Hospital. He completed his PhD in 2025 under the supervision of Prof Manchanda and Associate Prof Rosa Legood. His research focused on the prevention of ovarian and endometrial cancers including the PROTECTOR and PRESCORES studies. He studied medicine at the University of Cambridge and UCL before commencing Obstetrics & Gynaecology speciality training in the North Central and East London Deanery.

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Ashwin Kalra

Ashwin is a PhD student in Gynaecological Oncology. His work is based around the DETECT-2 randomised control trial, but includes working on our team’s projects in genetic testing, risk prediction, risk management, cancer prevention, and health economics. Ashwin studied Medicine at King’s College London and is a Specialty Trainee in Obstetrics and Gynaecology in the Kent, Surrey and Sussex Deanery. Ashwin’s research is supported by a grant from Barts Charity.

Lea-Mansour

Léa Mansour

Léa is an honorary Health Economics Research Associate and is evaluating the cost-effectiveness of the BRCA-DIRECT pilot, with a focus on genetic testing to shape public health policy and improve cancer prevention for women. Léa’s background in healthcare includes researching access disparities in maternity and midwifery care, alongside a clinical career in dentistry.

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Katrina Sarig

Katrina has specific expertise in genetic education and the development of screening services for at-increased risk communities. After completing her MSc in Organisational Psychology at UMIST, she managed R&D projects for an International behavioural risk management agency and as an independent consultant.  In 2009, Katrina founded Jnetics, the only UK charity dedicated to improving the prevention and management of Jewish genetic disorders. She left her Executive Director role at Jnetics in 2020 to establish and direct the JHC Review and work as an Honorary Research Fellow at the Centre for Cancer Prevention at Queen Mary University of London.

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Annika Idahl

Professor Annika Idahl joined QMUL for a research sabbatical in September 2023 to March 2024 and is now an Honorary reader in the WPP team. She is an appointed Professor of Obstetrics and Gynecology at Umeå University
in Sweden and a senior consultant at the University Hospital of Northern Sweden. She leads the MISSION-O – Menopausal impact of opportunistic salpingectomy for prevention of ovarian cancer in collaboration with Professor
Manchanda and his team.

Prof Idahl is a recognized university teacher at Umeå University. She is a member of several scientific advisory boards including the
Swedish Society of Obstetrics and Gynecology. Her research evolves around ovarian cancer early detection, prevention and epidemiology, and has more than 80 peer-reviewed publications. 

Rosa Legood

Rosa Legood

Rosa is an honorary Reader in Health Economics at QMUL. She has been collaborating with Ranjit Manchanda on health economics for over ten years. She is also an Associate Professor of Health Economics at London School of Hygiene and Tropical Medicine. She provides support the women’s prevention team regarding economic evaluation across a range of projects from clinical trials to pilot sites. She is also co-supervising several PhD students.

GCaPPS: Genetic Cancer Prediction through Population Screening
(2008-2019)

Following pre-test counselling and informed consent, 1034 Ashkenazi Jewish men and women were randomised to either population based or clinical criteria (family history) based genetic testing for BRCA founder mutations. Participants were followed up for three years after the test result. The study showed that compared to family-history based testing, population-based BRCA founder mutation testing doesn’t harm psychological health (anxiety, depression, health anxiety, distress, uncertainty)  or quality-of-life and identifies 150% additional BRCA carriers. Overall anxiety decreased with time. Long term follow up data shows a reduction in anxiety with population testing compared to family-history or clinical criteria based testing. We found BRCA testing in the Jewish population is acceptable, feasible, and can be undertaken in a community setting. It had high acceptability and was associated with 88% uptake and high satisfaction rates of ~95%. In a non-inferiority cluster-randomised trial we found that DVD-assisted pre-test counselling for population BRCA-testing is an effective, acceptable, non-inferior, time-saving and cost-efficient alternative to traditional genetic-counselling.

Our cost-effectiveness analysis shows, a population-based BRCA testing approach in the Ashkenazi Jewish population, reduces breast and ovarian cancer incidence, leading to up to an additional 33 days gain in life-expectancy and is extremely cost-effective (cost saving) with a discounted incremental cost-effectiveness ratio (ICER) = -£2960/quality adjusted life year (QALY). Probabilistic sensitivity analysis shows this remains cost-effective for 95% simulations at the £20,000/QALY NICE threshold. Our modelling suggests this could lead to 276 fewer ovarian and 508 fewer breast cancer cases in the UK. Overall, reduction in treatment costs could lead to a discounted cost savings of £3.7 million for the NHS.

Cost-effectiveness Population BRCA testing in Canada(2022-2024)
Evaluation of cost-effectiveness of population based BRCA testing in Canada. This project is being undertaken in collaboration with the team in British Columbia led by Prof Kwon and Prof Dawson.
PROMISE Feasibility Study
(2016-2019)
This pilot study into the impact of population based genetic testing for ovarian/breast cancer gene mutations recruited 103 women from the general population. It found that population-based testing is feasible and acceptable, has high satisfaction, reduces cancer worry/risk perception, and does not negatively impact psychological health/quality of life.
Cost-effectiveness analysis of multigene testing at breast cancer diagnosis

This study investigated whether offering unselected genetic testing of a panel of BRCA1/BRCA2/PALB2 genes to everyone diagnosed with breast cancer was cost-effective compared to the current model of BRCA1/BRCA2 testing based on a patient’s family history/clinical criteria. This study found that unselected panel gene testing for everyone at breast cancer diagnosis was highly cost-effective compared to the current model of testing for UK and US health systems, and could save 2101 cases of ovarian and breast cancer in the UK, and 2406 in the US per year.

Value based genetic technology for breast cancer in China. (2020-2023)

Evaluating cost-effectiveness of population based panel genetic testing for ovarian/breast cancer gene mutations in the general population (2016-2019)
This study evaluated the cost-utility of unselected genetic testing (for BRCA1/BRCA2/PALB2) for all patients diagnosed with breast cancer in the UK and USA, compared to the traditional family history/clinical criteria approach. Unselected testing was cost-effective in both systems, and could prevent 2101 cases of breast/ovarian cancer in the UK, and 9733 cases in the USA.
Cost-effectiveness analysis of multigene testing at breast cancer diagnosis

This study investigated whether offering unselected genetic testing of a panel of BRCA1/BRCA2/PALB2 genes to everyone diagnosed with breast cancer was cost-effective compared to the current model of BRCA1/BRCA2 testing based on a patient’s family history/clinical criteria. This study found that unselected panel gene testing for everyone at breast cancer diagnosis was highly cost-effective compared to the current model of testing for UK and US health systems, and could save 2101 cases of ovarian and breast cancer in the UK, and 2406 in the US per year.

Value based genetic technology for breast cancer in China. (2020-2023)

RRESDO Study

A multicentre UK cohort questionnaire study to determine risk-reducing early salpingectomy and delayed oophorectomy (RRESDO) acceptability and effect of surgical prevention on menopausal sequelae/satisfaction/regret in women at increased ovarian cancer (OC) risk.

We found that RRESDO has high acceptability among premenopausal women at increased ovarian cancer risk, particularly those concerned about sexual dysfunction.

Economic Evaluation of Population-Based BRCA1/BRCA2 Mutation Testing across Multiple Countries and Health Systems

This study evaluated the cost-effectiveness of population-based BRCA testing in general population women across different countries/health systems. Our findings are split across high-income (HIC), upper-middle income (UMIC) and low-middle income countries (LMIC). Our findings suggest that population-based BRCA testing for countries evaluated is extremely cost-effective across high (US/UK/Netherlands) and upper/middle income countries’ health systems (China/Brazil), is cost-saving for high-income health systems from a societal perspective, and can prevent tens of thousands more breast or ovarian cancer cases.

Defining the ‘risk thresholds’ for risk reducing salpingo-oophorectomy (RRSO) for ovarian cancer prevention

We for the first time defined the precise ovarian cancer risk thresholds at which risk reducing salpingo oophorectomy (preventive surgery) should be undertaken for ovarian cancer prevention in both pre- and post-menopausal women. 

Our findings show this is cost-effective in intermediate risk women too, saving 7-10 years of a woman’s life. This has significant implications for a number of women who currently can’t access risk reducing surgery. It also provides clinical utility for genetic testing of intermediate risk ovarian cancer genes. This has led to change in guidelines/practice for surgical prevention of ovarian cancer.

Previous projects supported by our team

Value based genetic technology for breast cancer in China (2020-2023)

Investigating BRCAness in epithelial ovarian cancer (EOC) in India to develop stratified surgical and chemotherapy options (2017-2020)

Correlation of p53 IHC expression with TP53 mutation status in Endometrial Carcinoma (Co-investigator) (2017-2019)

UK FOCSS – UK Familial Ovarian Cancer Screening Study

UKCTOCS – UK Collaborative Trial of Ovarian Cancer Screening

ALDO – Avoiding late diagnosis of ovarian cancer

Shape Up following cancer treatment

SOCQER2

Use of Plasmajet in ultra-radical surgery for advanced Ovarian Cancer (2015-2019)

SURAKSHA- South Asian Breast Cancer Risk Prediction, Genetic testing & Health Management programme (2020-2021)

SHAPE

STATEC

MAPPING

ROCkeTS

SCCAN

GROningen INternational Study on Sentinel nodes in Vulvar cancer (GROINSS-V)

For more details on these support projects, click here!

PROTECTOR: Preventing Ovarian Cancer Through early Excision of Tubes & late Ovarian Removal

PROTECTOR is a research study for women who are at an increased risk of developing ovarian cancer, due a strong family history of cancer, or an alteration in genes (such as BRCA1, BRCA2, RAD51C, RAD51D, BRIP1, or PALB2). This study assesses the impact of surgery to remove the fallopian tubes and ovaries to prevent ovarian cancer. 

Participants can choose whether to have no surgery, the usual operation to remove both tubes and ovaries, or a new 2-step approach of removing the fallopian tubes first followed by a second operation to remove the ovaries later. 

The study assesses the impact of these surgeries on sexual function, hormone levels, quality of life and overall satisfaction. 41 sites across the UK are recruiting. PROTECTOR is funded by Barts Charity & Rosetrees Trust.

PROTECTOR Phase 1 has completed recruitment, and we are looking to open for Phase 2 in January 2025. 

For more information please visit: http://www.protector.org.uk/
DETECT-2: Direct to Patient testing at Cancer diagnosis for Precision Prevention-2

DETECT-2 is a study investigating if genetic testing can be offered to people in their own home.

In this study, participants who have been diagnosed with ovarian, womb, or bowel cancer are randomly assigned to be offered either conventional genetic testing by their cancer team or genetic testing at home. This new model is called “direct-to-patient” testing and includes offering genetic testing information on an interactive app or website, and offering genetic testing by a home saliva kit posted to participants.

DETECT-2 will assess if direct-to-patient genetic testing impacts participants’ willingness to accept genetic testing, or has an impact on their quality-of-life, satisfaction, or mental wellbeing. It will also assess if direct-to-patient testing is cost-effective.

DETECT-2 is supported by GSK and the North East London Cancer Alliance

For more information please visit: https://www.detect-2.co.uk/
PRESCORES: Prevention of endometrial cancer: Utility scores of risk-reducing strategies
PRESCORES is a research study looking into the quality of life of women after an operation to prevent womb (endometrial) cancer. This operation is known as risk-reducing hysterectomy. We will use this to understand whether more people at risk of this cancer could benefit from this operation.
PROTECT-C: Population based germline testing for early detection and prevention of cancer

PROTECT-C is offering genetic testing to women (women, trans men and non-binary people with female reproductive organs) to see if they have an increased risk of breast, ovary, bowel and/or womb cancer. This is regardless of whether they or their families have had cancer.

Specially trained counsellors are available through a helpline (telephone, virtual, email). If a participant decides to proceed with genetic testing, they will be sent a saliva kit for genetic testing at home (a “direct-to-patient” approach).

PROTECT-C aims to find out how many women decide to have genetic testing, their experience, and how this affects their quality of life, satisfaction and mental well-being. 

PROTECT-C will assess the number of people identified to be at increased risk, and how many of them take up screening and prevention options. The study will also assess whether it is cost-effective for the NHS to offer genetic testing to all women in the population.

PROTECT-C is funded by a £3.89 million research grant from Yorkshire Cancer Research, and is aiming to launch in 2025.

For more information please visit: https://protect-c.co.uk

JHCR: The Jewish Hereditary Cancer Review

This project aims to review the status of BRCA awareness, community support and BRCA testing provision, experience and satisfaction in the ‘at-increased-risk’ Jewish community in the UK.

The review will focus on hereditary cancers associated with BRCA1 and BRCA2 gene mutations. It will concentrate on the provision of BRCA information and testing in the UK and also look at BRCA-related activities in Jewish communities internationally.

Delivery of the research will be carried out by researchers based at Queen Mary University of London in partnership with the JHCR project director, and under the guidance of expert advisors.

Research outcomes will help identify priority needs and recommendations to improve BRCA awareness in, and access to responsible BRCA testing for, the UK Jewish community.

Findings will be published in a community report and scientific papers – raising awareness and promoting positive action to improve hereditary cancer management and prevention in the UK Jewish community.

OVACATCH: Ovarian Cancer Targeted Early Detection for Faster Diagnosis at a Curable Stage

Ovarian cancer is typically diagnosed at a late stage which is associated with a worse prognosis. There are also no effective screening tests available for ovarian cancer. 

OVACATCH aims to improve earlier diagnosis of ovarian cancer or identify cancers that current investigations may miss, by using longitudinal multiple biomarker algorithms derived from serum blood tests.

These will be validated using prospectively collected longitudinal serum samples held in biobanks from women with cancer diagnoses and healthy controls. A prospective cohort screening trial will then be conducted to evaluate these multi-marker algorithms compared to current methods of ovarian cancer surveillance using ROCA (Risk of Ovarian Cancer Algorithm). 

OVACATCH will evaluate false positive rate, feasibility, compliances, satisfaction and anxiety with screening. This will provide the initial data needed to design a large multicentre screening trial for ovarian cancer, moving the needle forward towards developing an effective screening strategy for ovarian cancer.

SECRETS: Serous endometrial cancer risk and role of risk-reducing hysterectomy in BRCA carriers

The current literature around risk of serous endometrial cancer in BRCA pathogenic variant (PV) carriers is equivocal. There have been few studies that have stratified the risk in serous endometrial cancers and none focusing specifically on this histopathological subtype of endometrial cancer.

 There have been no case-control studies to address this issue and the cohort studies demonstrating increased risk report large confidence intervals, while some others found no increase in risk. The true prevalence of BRCA1/BRCA2 PVs in prospective unselected UK serous EC patients is unknown. There remains continued uncertainty around whether BRCA1 PV carriers should undergo preventive hysterectomy (or not).

This study will address knowledge gaps such as the risk of serous endometrial cancer in patients with BRCA1/BRCA2 PVs, if hysterectomy would be cost-effective in the UK for BRCA1 and BRCA2 PV carriers, and if hysterectomy is acceptable alongside risk-reducing salpingo-oophorectomy for these carriers. 

UKCOGS: UK COVID and Gynaecological Cancer Study 

UKCOGS is a national study into the changes in diagnosis and treatment of gynaecological oncology patients that occurred in response to COVID-19. It aims to understand the decisions made by multi-disciplinary teams working in gynaecological oncology hospitals, the changes that occurred in these hospitals, and the impact of these changes on the health and survival of cancer patients.

The study is endorsed and supported by the British Gynaecological Cancer Society, Royal College of Obstetricians and Gynaecologists, NCRI Gynaecological Cancer Clinical Studies Group, British Association of Gynaecological Pathologists, and charities including Ovacome, The Eve Appeal, Target Ovarian Cancer, Ovarian Cancer Action, Jo’s Cervical Cancer trust and GO Girls.

SIGNPOST: Systematic genetic testing for personalised ovarian cancer therapy (SIGNPOsT)

Genetic testing in ovarian cancer patients is now being implemented across the NHS.  It’s hoped that by doing this, patients across the NHS will have even better treatments and that in some families, cancers will be prevented. This trial offers a genetic test to women with certain types of ovarian cancer. This is to detect gene alterations that may be a cause of ovarian cancer.

In this study we aim to find out more about:

  • what effect genetic counselling has on women’s emotional quality of life 
  • the gene changes women with ovarian cancer have
  • whether women with gene changes choose to have screening or treatment to prevent ovarian cancer
  • what are the costs of this new genetic testing strategy 

We also want to investigate the factors that affect the risk of developing ovarian cancer. This includes looking at how gene changes and other factors that might affect:

  • the risk of getting it
  • treatment 
  • how well the treatment works (outcome) 

SIGNPOST entails collecting samples including cancer, blood, and genetic information. 

The study is open to women who:

  • have had genetic testing 
  • have been offered testing but refused
  • haven’t had testing
Evaluation of the BRCA-Direct SBRI programme

The team has conducted a service evaluation of the BRCA-DIRECT pathway to assess the impact of implementing unselected genetic testing at the point of breast cancer diagnosis in London.

This evaluation encompassed clinical service performance, cost-effectiveness modelling, and patient satisfaction.

We have preliminary data we have presented recently at the BGCS Annual Scientific Meeting, and are working towards disseminating these results soon. 

Evaluation of NHS Jewish BRCA Testing Programme
The Jewish BRCA Testing Programme is being implemented by the NHS National Cancer Programme team, working with ICR, North Thames GLH, Royal Marsden Hospital, Manchester and QMUL teams along with community organisations and stakeholders including Chai Cancer Care and Jnetics.

For more information please visit J-BRCA (nhsjewishbrcaprogramme.org.uk)

Genetic testing for Lynch syndrome at endometrial cancer diagnosis e-learning modules
This teaching programme aims to develop the skills, knowledge, and confidence of gynaecology and gynaecological cancer care professionals in delivering testing for Lynch syndrome for patients diagnosed with endometrial cancer. This is to support implementation of the national standard set by NICE diagnostic guidance 42 as well as other national and international guidelines on Lynch syndrome testing for all women with endometrial cancer. 
Acceptability of risk-reducing strategies at different lifetime risk thresholds to reduce the risk of breast cancer

Now that we have identified the lifetime risk threshold of breast cancer at which a risk-reducing mastectomy (RRM) would be cost-effective, it is important prior to clinical implementation to evaluate the acceptability of this risk-reducing strategy. 

We will be undertaking a vignette study and randomising general population women into 5 groups with different lifetime risks of breast cancer, and asking a series of questions on acceptability of RRM. 

MISSION-O: Menopausal Impact of Opportunistic Salpingectomy for Ovarian Cancer Prevention

Previous studies have analyzed complications and menopausal symptoms of opportunistic salpingectomy (removing the fallopian tubes during other gynecological surgeries), but so far have not evaluated the age of menopause – an important factor because early menopause can have negative consequences for bone health, the cardiovascular system, sexual health and cognitive function.

We will analyze blood samples from participants in the HOPPSA study, where 2,700 women have undergone hysterectomy with or without opportunistic salpingectomy. They are offered to provide blood samples on two occasions: 1–8 and 2–9 years after the operation. In this way, we can compare the age of menopause between those who have undergone opportunistic salpingectomy and those who have not.

Cost-effectiveness of colorectal cancer screening for people in the UK with Lynch syndrome

This project will evaluate the cost-effectiveness of colorectal cancer surveillance for people in the UK with Lynch syndrome, in collaboration with teams at St Mark’s Hospital and Amsterdam University Medical Center (UMC).

Using retrospective, patient-level colonoscopy records and established colorectal cancer simulation models adapted for Lynch syndrome, we will estimate the costs and health outcomes of alternative surveillance schedules. Results may help quantify the potential benefits of identifying Lynch syndrome via genetic testing and inform future policy and guideline development for colorectal cancer prevention in this population.